Time-reversed ultrasonically encoded optical focusing into scattering media

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Time-reversed ultrasonically encoded optical focusing into scattering media

Light focusing plays a central role in biomedical imaging, manipulation, and therapy. In scattering media, direct light focusing becomes infeasible beyond one transport mean free path. All previous methods1-3 to overcome this diffusion limit lack a practical internal "guide star."4 Here we proposed and experimentally validated a novel concept, called Time-Reversed Ultrasonically Encoded (TRUE) ...

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Analog time-reversed ultrasonically encoded light focusing inside scattering media with a 33,000× optical power gain

Recent breakthrough in wavefront engineering shows great promises in controlling light propagation inside scattering media. At present, the digital approaches enjoy high gain, while their speeds are slow because of high data throughputs. In contrast, the analog approaches are intrinsically fast but suffer from poor efficiencies and small gains. Further improvements in both speed and gain are ne...

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Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light.

Focusing light deep inside living tissue has not been achieved despite its promise to play a central role in biomedical imaging, optical manipulation and therapy. To address this challenge, internal-guide-star-based wavefront engineering techniques--for example, time-reversed ultrasonically encoded (TRUE) optical focusing--were developed. The speeds of these techniques, however, were limited to...

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Reflection-mode time-reversed ultrasonically encoded optical focusing into turbid media.

Time-reversed ultrasonically encoded (TRUE) optical focusing was recently proposed to deliver light dynamically to a tight region inside a scattering medium. In this letter, we report the first development of a reflection-mode TRUE optical focusing system. A high numerical aperture light guide is used to transmit the diffusely reflected light from a turbid medium to a phase-conjugate mirror (PC...

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Frequency-swept time-reversed ultrasonically encoded optical focusing.

A technique to rapidly scan an optical focus inside a turbid medium is attractive for various biomedical applications. Time-reversed ultrasonically encoded (TRUE) optical focusing has previously demonstrated light focusing into a turbid medium, using both analog and digital devices. Although the digital implementation can generate a focus with high energy, it has been time consuming to scan the...

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ژورنال

عنوان ژورنال: Nature Photonics

سال: 2011

ISSN: 1749-4885,1749-4893

DOI: 10.1038/nphoton.2010.306